*Intended for Oral Use in Horses*UNIPRIM POWDER is a combination of trimethoprim and sulfadiazine in the ratio of 1 part to 5 parts by weight which provides effective antibacterial activity against a wide range of bacterial infections in animals.
Mode of Action:
Microbiology: Trimethoprim blocks bacterial production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase.
Sulfadiazine, in common with other sulfonamides, inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid.
Trimethoprim/sulfadiazine thus imposes a sequential double blockade of bacterial metabolism. This deprives bacteria of nucleic acids and proteins essential for survival and multiplication, and produces a high level of antibacterial activity which is usually bactericidal.
The recommended dose is 3.75 g trimethoprim/sulfadiazine per 110 lbs (50 kg) body weight per day. Administer trimethoprim/sulfadiazine powder orally once a day in a small amount of palatable feed. The usual course of treatment is a single, daily dose for five to seven days.